Filippo Vairo is an Associate Consultant in the Department of Clinical Genomics and in the Center for Individualized Medicine at Mayo Clinic where he is the Medical Director of the Program for Rare and Undiagnosed Disease (PRaUD). Also, he is Assistant Professor of Medical Genetics in the Mayo Clinic College of Medicine and Science. Dr Vairo is one of the organizers of the Latin American School of Human and Medical Genetics and since 2008 he organizes the Advanced Course on Diagnosis and Treatment of Inherited Diseases. He is member of the Editorial Board of the Journal of Inborn Errors of Metabolism and Screening, and affiliated member of the Brazilian National Academy of Medicine. Since 2016, he is member of the Mayo Clinic Center for Individualized Medicine (CIM) Translational Omics Program (TOP) where he has been aiding in establishing several innovative techniques to assist in patient practice in the area of individualized medicine. Also, he is involved in developing and/or implementing novel methodologies for the identification of genetic variation causing disease and to functionally validate variant pathogenicity to ultimately increase the number of patients receiving a genetic diagnosis. He has experience in the area of clinical genetics, inborn errors of metabolism and lysosomal diseases, and precision medicine. Dr Vairo’s research interests include new diagnostic tools and translational medicine.